Disease: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t (11;15) (q23;q14) with MLL/HRX. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 FYVE-type zinc finger. tissue specificity: Detected in brain, heart, skeletal muscle, kidney and liver.