Caution: This may not be the true ortholog of mouse OASL. function: Does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNA. induction: By interferons. similarity: Belongs to the 2-5A synthetase family. similarity: Contains 2 ubiquitin-like domains. subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1. tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.