AffiAB® JMY Rabbit Polyclonal Antibody

Function: Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. induction: By E2F. PTM: Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response. similarity: Contains 1 WH2 domain. subunit: Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.