AffiAB® NPY6R Rabbit Polyclonal Antibody

Caution: Could be the product of a pseudogene. According to PubMed: 97066888, PubMed: 97066971 and PubMed: 9013614, the human NPY6R gene is an expressed pseudogene containing a premature stop codon and encoding a non-functional truncated protein missing the last transmembrane domain. A single base pair deletion relative to the mouse ortholog, results in a truncated protein lacking the seventh transmembrane domain. function: When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function. similarity: Belongs to the G-protein coupled receptor 1 family. tissue specificity: Expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain and adrenal glands.