AffiAB® Anti-Hu C5aR2 PE

C5aR2, also known as C5L2, is one of two receptors for C5a (anaphylatoxin) . It is coexpressed with C5aR1 (CD88) in neutrophils, as well as e.g. in mast cells, astrocytes, or macrophages, and seems to have both pro-inflammatory and anti-inflammatory roles, depending on circumstances. Unlike CD88, C5aR2 is not coupled to G-protein, thus the modulatory role is more likely.