AffiAB® LRIG1 Rabbit Polyclonal Antibody

Domain: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted. function: Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. induction: By EGF. similarity: Contains 17 LRR (leucine-rich) repeats. similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. subunit: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. tissue specificity: Widely expressed.