Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. similarity: Belongs to the tomoregulin family. similarity: Belongs to the UPF0439 family. similarity: Contains 1 EGF-like domain. similarity: Contains 2 Kazal-like domains. subunit: May interact with ST14. tissue specificity: Expressed in brain. tissue specificity: Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.