Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains. function: May be involved in Ca (2+)-dependent exocytosis of secretory vesicles through Ca (2+) and phospholipid binding to the C2 domain or may serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis. similarity: Belongs to the synaptotagmin family. similarity: Contains 2 C2 domains. tissue specificity: Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.