Phosphatidylinositol-4, 5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI (3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K (s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.