AffiAB® BinCARD Rabbit Polyclonal Antibody

Function: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 CARD domain. subcellular location: Co-expression with BCL10 induced translocation from nucleus to cytosol. subunit: Associates with BCL10 by CARD-CARD interaction. tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.