Induction: In keratinocytes, by wounding or contact with collagen. similarity: Belongs to the epsin family. similarity: Contains 1 ENTH (epsin N-terminal homology) domain. similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats. subcellular location: Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus. tissue specificity: Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis.