AffiAB® BEX3 Rabbit Polyclonal Antibody

Domain: The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR. function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. miscellaneous: Binds transition metals. PTM: Ubiquitinated. Degraded by the proteasome. similarity: Belongs to the BEX family. subcellular location: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. subunit: Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR. tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.