A Comprehensive Guide to P-Cadherin Research and Applications
CADH3, also known as P-cadherin or Cadherin-3, is a key protein in molecular biology and medical research, widely studied for its role in cell adhesion and tissue architecture. This guide breaks down what CADH3 is, why it matters in science, and how high-quality reagents like the AffiAB® CADH3 Antibody fuel cutting-edge research.
Sections
1What Is CADH3 (P‑Cadherin)?
CADH3 stands for Cadherin‑3 (GeneCards), a member of the cadherin superfamily of calcium‑dependent adhesion proteins. These membrane‑associated proteins help cells stick together, playing an essential role in cell adhesion, tissue integrity, and developmental processes. ScienceDirecte
- It’s often called P‑cadherin (P for placental), reflecting its early discovery and abundant expression in specific tissues.
- Like other cadherins, CADH3 contains repeating domains (~110 amino acids each) that mediate homophilic binding meaning CADH3 molecules on adjacent cells connect with each other in a calcium‑dependent manner.
Because of this function, CADH3 is widely studied in cell biology, tissue engineering, and cancer research.
2Why CADH3 Matters in Research?
1. Cell Adhesion and Tissue Dynamics
CADH3’s primary biological role is mediating cell-to-cell interaction, essential for maintaining tissue architecture. Disruption of CADH3 expression can influence how cells migrate and interact factors that are key in development and disease processes.
2. Emerging Role in Cancer Biology
Recent studies exploring CADH3 expression in cancer highlight its potential as a biomarker or therapeutic target:
- Research indicates that high CADH3 expression can correlate with drug sensitivity in certain tumor types. For instance, drugs like afatinib an EGFR inhibitor have shown stronger effects in cancer cells with elevated CADH3 levels. This suggests CADH3 may influence how tumors respond to targeted therapy.
Although not yet a clinical target approved by major regulatory bodies like the FDA, such findings fuel ongoing investigations into diagnostic and therapeutic applications involving CADH3.
3Studying CADH3 With Antibodies
High‑quality antibodies are indispensable tools in research for detecting and quantifying proteins like CADH3 in cells and tissues. One such reagent is:
🧬 AffiAB® CADH3 Antibody
This research‑grade protein antibody is designed to help scientists study CADH3 expression patterns in experiments such as:
- Western blot.
- Immunohistochemistry (IHC).
- Flow cytometry.
- Immunoprecipitation.
It is part of the AffiAB® line of research antibodies, known for specificity and reproducibility in lab settings.
The presence of consistent, validated tools like this antibody empowers researchers to generate reliable data for publications, presentations, and discovery pipelines.
4CADH3 in Modern Science
CADH3 (P-cadherin) plays a critical role in cellular adhesion and is increasingly studied in contexts ranging from tissue biology to cancer research. As scientists continue to unravel its complex biology, research tools such as the AffiAB® CADH3 Antibody support precise and reliable investigations into CADH3’s function and potential applications.
Staying updated with the latest in CADH3 research from protein expression studies to drug response correlations positions labs at the forefront of discovery in cell biology and translational science.
For more details or to source the AffiAB® CADH3 Antibody, visit the official product page.
